Endocrine Abstracts

Introduction: Rapid-acting insulins is widely used in the treatment of either type 1 diabetes mellitus, or type 2 diabetes mellitus. A mealtime injection of rapid-acting insulin, such as insulin aspart, allow the diabetic patients to control the levels of post-prandial glucose. The clinical development plan of the insulin biosimilarsusually contains pharmacology studies to evaluate pharmacokinetics (PK), pharmacodynamics (PD) and clinical safety of the investigational products...

IntroductionNowadays thrombopoietin receptor agonists (TPO-RAs) represent a promising approach for the patients with immune thrombocytopenia (ITP). Usage of two licensed TPO-RAs, romiplostim and eltrombopag, provide efficient support of ITP patients´ platelet count and, as a consequence, better control of disease. Both agents have an acceptable toxicity profile, but there are several another disadvantages in terms of usage of these drugs such as cos...